Stv. Chefarzt
Priv.-Doz. Dr. med. Maciej Malinowski, MHBA
Facharzt für Allgemeinchirurgie, Facharzt für Viszeralchirurgie, Zusatzbezeichnungen: Spezielle Viszeralchirurgie, Intensivmedizin
Studium
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- 1. Humanmedizinische Fakultät, Akademia Medyczna im. Karola Marcinkowskiego, Poznań, Polen
Dissertation
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- „The direct and systemic influence of immunosuppressive drugs on intestinal glucose absorption, barrier function and chloride secretion in rat models“
Prof. P. Neuhaus, Charité Universitätsmedizin, Berlin
Habilitation
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- Venia Legendi für das Fach Chirurgie, Habilitationsschrift zum Thema: „Leberresektion in Tumorpatienten: wie kann das postoperative Ergebnis verbessert werden?“
Universitätsklinikum des Saarlandes, Homburg (Prof. Glanemann)
Klinische Scherpunkte
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- Onkologische Viszeralchirurgie
- Minimalinvasive Chirurgie
Mitglied in folgenden Fachgesellschaften
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- DGCH (Deutsche Gesellschaft für Chirurgie)
- DGAV (Deutsche Gesellschaft für Allgemein- und Viszeralchirurgie)
- ACO (Assoziation chirurgische Onkologie, DGAV)
- ESSO (European Society of Surgical Oncology)
- BDC (Berufsverband der Deutschen Chirurgie)
Wissenschaftliche Preise und Stipendien
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- Promotionsstipendium der Charité, Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Charité Universitätsmedizin, Berlin, Deutschland
- Reisestipendium der Deutschen Gesellschaft für Chirurgie, Hospitation in der Klinik für Hepatobiliäre Chirurgie, Universität Tokio
Klinischer und akademischer Werdegang
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- seit 01/2024 Stv. Chefarzt der Klinik für Allgemein-, Viszeral-, Thorax- und Tumorchirurgie, CaritasKlinikum Sarbrücken (Prof. R. Metzger)
- 06/2023 Venia Legendi für das Fach Chirurgie, Habilitationsschrift zum Thema: „Leberresektion in Tumorpatienten: wie kann das postoperative Ergebnis verbessert werden?“
- 10/2019 bis 10/2021 Berufsbegleitender Studiengang: Master of Health Business Administration an der Universität Erlangen-Nürnberg Masterarbeit zum Thema: „Der Einsatz von Ansätzen zur minimally important difference (MID) in der Onkologie“
- 04/2018 – 12/2023 Oberarzt Klinik für Allgemeine Chirurgie, Viszeral-, Gefäß- und Kinderchirurgie (Prof. Dr. M. Glanemann)
- 08/2015 bis 03/2018 Facharzt Klinik für Allgemeine Chirurgie, Viszeral-, Gefäß- und Kinderchirurgie (Prof. Dr. M. Glanemann)
- 2005 - 2016 wissenschaftlicher Mitarbeiter in der AG: „Workgroup for The Liver“, Charité Universitätsmedizin, Berlin, Deutschland (Prof. M. Stockmann)
- 10/2011 Disputation zum Thema: The direct and systemic influence of immunosuppressive drugs on intestinal glucose absorption, barrier function and chloride secretion in rat models.
Benotung: magna cum laude - 07/2007 bis 08/2015 Assistenzarzt und Facharzt Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Charité Universitätsmedizin, Berlin, Deutschland (Prof. P. Neuhaus, Prof. J Pratschke)
- 2004 – 2007 Promotionsstudent
- 2003 – 2004 Arzt im Praktikum IV. Krankenhaus, Hausarztpraxis, Notarzt in Bytom, Polen
- 1997 – 2003 Humanmedizinstudium 1. Humanmedizinische Fakultät, Akademia Medyczna im. Karola Marcinkowskiego, Poznań, Polen
Veröffentlichungen, Publikationen
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- Lock, J.F., T. Reinhold, M. Malinowski, J. Pratschke, P. Neuhaus, and M. Stockmann, The costs of postoperative liver failure and the economic impact of liver function capacity after extended liver resection--a single-center experience. Langenbecks Arch Surg, 2009. 394(6): p. 1047-56.
- Lock, J.F., P. Taheri, S. Bauer, H.G. Holzhutter, M. Malinowski, P. Neuhaus, and M. Stockmann, Interpretation of non-invasive breath tests using (13)C-labeled substrates--a preliminary report with (13)C-methacetin. Eur J Med Res, 2009. 14: p. 547-50.
- Malinowski, M., P. Martus, P. Neuhaus, and M. Stockmann, The influence of commonly used immunosuppressive drugs on the small bowel functions - a comparative experimental study. Ann Transplant, 2009. 14(2): p. 38-44.
- Stockmann, M., M. Malinowski, J.F. Lock, D. Seehofer, and P. Neuhaus, Factors influencing the indocyanine green (ICG) test: additional impact of acute cholestasis. Hepatogastroenterology, 2009. 56(91-92): p. 734-8.
- Lock, J., T. Reinhold, A. Bloch, M. Malinowski, S.C. Schmidt, P. Neuhaus, and M. Stockmann, The cost of graft failure and other severe complications after liver transplantation - experience from a German Transplant Center. Ann Transplant, 2010. 15(3): p. 11-8.
- Lock, J.F., E. Schwabauer, P. Martus, N. Videv, J. Pratschke, M. Malinowski, P. Neuhaus, and M. Stockmann, Early diagnosis of primary nonfunction and indication for reoperation after liver transplantation. Liver Transpl, 2010. 16(2): p. 172-80.
- Malinowski, M., J. Pratschke, J. Lock, P. Neuhaus, and M. Stockmann, Effect of tacrolimus dosing on glucose metabolism in an experimental rat model. Ann Transplant, 2010. 15(3): p. 60-5.
- Niehues, S.M., J.K. Unger, M. Malinowski, J. Neymeyer, B. Hamm, and M. Stockmann, Liver volume measurement: reason of the difference between in vivo CT-volumetry and intraoperative ex vivo determination and how to cope it. Eur J Med Res, 2010. 15(8): p. 345-50.
- Stockmann, M., J.F. Lock, M. Malinowski, S.M. Niehues, D. Seehofer, and P. Neuhaus, The LiMAx test: a new liver function test for predicting postoperative outcome in liver surgery. HPB (Oxford), 2010. 12(2): p. 139-46.
- Stockmann, M., J.F. Lock, M. Malinowski, D. Seehofer, G. Puhl, J. Pratschke, and P. Neuhaus, How to define initial poor graft function after liver transplantation? - a new functional definition by the LiMAx test. Transpl Int, 2010. 23(10): p. 1023-32.
- Lock, J.F., M. Malinowski, E. Schwabauer, P. Martus, J. Pratschke, D. Seehofer, G. Puhl, P. Neuhaus, and M. Stockmann, Initial liver graft function is a reliable predictor of tacrolimus trough levels during the first post-transplant week. Clin Transplant, 2011. 25(3): p. 436-43.
- Malinowski, M., P. Martus, J.F. Lock, P. Neuhaus, and M. Stockmann, Systemic influence of immunosuppressive drugs on small and large bowel transport and barrier function. Transpl Int, 2011. 24(2): p. 184-93.
- Lock, J.F., M. Malinowski, D. Seehofer, S. Hoppe, R.I. Rohl, S.M. Niehues, P. Neuhaus, and M. Stockmann, Function and volume recovery after partial hepatectomy: influence of preoperative liver function, residual liver volume, and obesity. Langenbecks Arch Surg, 2012. 397(8): p. 1297-304.
- Faber, W., S. Sharafi, M. Stockmann, T. Denecke, B. Sinn, G. Puhl, M. Bahra, M. Malinowski, P. Neuhaus, and D. Seehofer, Long-term results of liver resection for hepatocellular carcinoma in noncirrhotic liver. Surgery, 2013. 153(4): p. 510-7.
- Geisel, D., L. Ludemann, T. Keuchel, M. Malinowski, D. Seehofer, M. Stockmann, B. Hamm, B. Gebauer, and T. Denecke, Increase in left liver lobe function after preoperative right portal vein embolisation assessed with gadolinium-EOB-DTPA MRI. Eur Radiol, 2013. 23(9): p. 2555-60.
- Kaffarnik, M.F., J.F. Lock, H. Vetter, N. Ahmadi, C. Lojewski, M. Malinowski, P. Neuhaus, and M. Stockmann, Early diagnosis of sepsis-related hepatic dysfunction and its prognostic impact on survival: a prospective study with the LiMAx test. Crit Care, 2013. 17(5): p. R259.
- Lock, J.F., A.N. Kotobi, M. Malinowski, A. Schulz, M. Jara, P. Neuhaus, and M. Stockmann, Predicting the prognosis in acute liver failure: results from a retrospective pilot study using the LiMAx test. Ann Hepatol, 2013. 12(4): p. 556-62.
- Brinkhaus, G., J.F. Lock, M. Malinowski, T. Denecke, P. Neuhaus, B. Hamm, B. Gebauer, and M. Stockmann, CT-guided high-dose-rate brachytherapy of liver tumours does not impair hepatic function and shows high overall safety and favourable survival rates. Ann Surg Oncol, 2014. 21(13): p. 4284-92.
- Faber, W., S. Sharafi, M. Stockmann, T. Dennecke, M. Bahra, F. Klein, M. Malinowski, E. Schott, P. Neuhaus, and D. Seehofer, Patient age and extent of liver resection influence outcome of liver resection for hepatocellular carcinoma in non-cirrhotic liver. Hepatogastroenterology, 2014. 61(135): p. 1925-30.
- Geisel, D., B. Gebauer, M. Malinowski, M. Stockmann, and T. Denecke, Comparison of CT and MRI artefacts from coils and vascular plugs used for portal vein embolization. Eur J Radiol, 2014. 83(4): p. 692-5.
- Geisel, D., L. Ludemann, B. Gebauer, V. Froling, V. Prasad, U. Heimann, M. Stockmann, M. Malinowski, B. Hamm, W. Brenner, and T. Denecke, Optimized separation of left and right liver lobe in dynamic (99m)Tc-mebrofenin hepatobiliary scintigraphy using a hybrid SPECT-CT scanner. Ann Nucl Med, 2014. 28(9): p. 897-902.
- Geisel, D., L. Ludemann, C. Wagner, L. Stelter, C. Grieser, M. Malinowski, M. Stockmann, D. Seehofer, B. Hamm, B. Gebauer, and T. Denecke, Evaluation of gadolinium-EOB-DTPA uptake after portal vein embolization: value of an increased flip angle. Acta Radiol, 2014. 55(2): p. 149-54.
- Geisel, D., M. Malinowski, M.J. Powerski, J. Wustefeld, V. Heller, T. Denecke, M. Stockmann, and B. Gebauer, Improved hypertrophy of future remnant liver after portal vein embolization with plugs, coils and particles. Cardiovasc Intervent Radiol, 2014. 37(5): p. 1251-8.
- Jara, M., J. Bednarsch, J.F. Lock, M. Malinowski, A. Schulz, D. Seehofer, and M. Stockmann, [Enhancing safety in liver surgery using a new diagnostic tool for evaluation of actual liver function capacity - The LiMAx test]. Dtsch Med Wochenschr, 2014. 139(8): p. 387-91.
- Jara, M., J. Bednarsch, M. Malinowski, K. Luttgert, J. Orr, G. Puhl, D. Seehofer, P. Neuhaus, and M. Stockmann, Predictors of quality of life in patients evaluated for liver transplantation. Clin Transplant, 2014. 28(12): p. 1331-8.
- Jara, M., A. Schulz, M. Malinowski, G. Puhl, J.F. Lock, D. Seehofer, P. Neuhaus, and M. Stockmann, Growth hormone/insulin-like growth factor 1 dynamics in adult living donor liver transplantation. Liver Transpl, 2014. 20(9): p. 1118-26.
- Malinowski, M., M. Jara, K. Luttgert, J. Orr, J.F. Lock, E. Schott, and M. Stockmann, Enzymatic liver function capacity correlates with disease severity of patients with liver cirrhosis: a study with the LiMAx test. Dig Dis Sci, 2014. 59(12): p. 2983-91.
- Gebhardt, S., M. Jara, M. Malinowski, D. Seehofer, G. Puhl, J. Pratschke, and M. Stockmann, Risk factors of metabolic disorders after liver transplantation: an analysis of data from fasted patients. Transplantation, 2015. 99(6): p. 1243-9.
- Geisel, D., L. Ludemann, V. Froling, M. Malinowski, M. Stockmann, A. Baron, B. Gebauer, D. Seehofer, V. Prasad, and T. Denecke, Imaging-based evaluation of liver function: comparison of (9)(9)mTc-mebrofenin hepatobiliary scintigraphy and Gd-EOB-DTPA-enhanced MRI. Eur Radiol, 2015. 25(5): p. 1384-91.
- Hoppe, S., C. von Loeffelholz, J.F. Lock, S. Doecke, B.V. Sinn, A. Rieger, M. Malinowski, A.F. Pfeiffer, P. Neuhaus, and M. Stockmann, Nonalcoholic steatohepatits and liver steatosis modify partial hepatectomy recovery. J Invest Surg, 2015. 28(1): p. 24-31.
- Jara, M., J. Bednarsch, E. Valle, J.F. Lock, M. Malinowski, A. Schulz, D. Seehofer, T. Jung, and M. Stockmann, Reliable assessment of liver function using LiMAx. J Surg Res, 2015. 193(1): p. 184-9.
- Jara, M., M. Malinowski, K. Luttgert, E. Schott, P. Neuhaus, and M. Stockmann, Prognostic value of enzymatic liver function for the estimation of short-term survival of liver transplant candidates: a prospective study with the LiMAx test. Transpl Int, 2015. 28(1): p. 52-8.
- Jara, M., T. Reese, M. Malinowski, E. Valle, D. Seehofer, G. Puhl, P. Neuhaus, J. Pratschke, and M. Stockmann, Reductions in post-hepatectomy liver failure and related mortality after implementation of the LiMAx algorithm in preoperative work-up: a single-centre analysis of 1170 hepatectomies of one or more segments. HPB (Oxford), 2015. 17(7): p. 651-8.
- Malinowski, M., D. Geisel, V. Stary, T. Denecke, D. Seehofer, M. Jara, A. Baron, J. Pratschke, B. Gebauer, and M. Stockmann, Portal vein embolization with plug/coils improves hepatectomy outcome. J Surg Res, 2015. 194(1): p. 202-11.
- Malinowski, M., V. Stary, J.F. Lock, A. Schulz, M. Jara, D. Seehofer, B. Gebauer, T. Denecke, D. Geisel, P. Neuhaus, and M. Stockmann, Factors influencing hypertrophy of the left lateral liver lobe after portal vein embolization. Langenbecks Arch Surg, 2015. 400(2): p. 237-46.
- Bednarsch, J., E. Bluthner, M. Malinowski, D. Seehofer, J. Pratschke, and M. Stockmann, Regeneration of Liver Function Capacity After Partial Liver Resection is Impaired in Case of Postoperative Bile Leakage. World J Surg, 2016. 40(9): p. 2221-8.
- Bednarsch, J., M. Menk, M. Malinowski, S. Weber-Carstens, J. Pratschke, and M. Stockmann, (13) C Breath Tests Are Feasible in Patients With Extracorporeal Membrane Oxygenation Devices. Artif Organs, 2016. 40(7): p. 692-8.
- Jara, M., J. Bednarsch, M. Malinowski, J. Pratschke, and M. Stockmann, Effects of oxaliplatin-based chemotherapy on liver function--an analysis of impact and functional recovery using the LiMAx test. Langenbecks Arch Surg, 2016. 401(1): p. 33-41.
- Malinowski, M., J.F. Lock, D. Seehofer, B. Gebauer, A. Schulz, L. Demirel, J. Bednarsch, V. Stary, P. Neuhaus, and M. Stockmann, Preliminary study on liver function changes after trisectionectomy with versus without prior portal vein embolization. Surg Today, 2016. 46(9): p. 1053-61.
- Geisel, D., P. Raabe, L. Ludemann, M. Malinowski, M. Stockmann, D. Seehofer, J. Pratschke, B. Hamm, and T. Denecke, Gd-EOB-DTPA-enhanced MRI for monitoring future liver remnant function after portal vein embolization and extended hemihepatectomy: A prospective trial. Eur Radiol, 2017. 27(7): p. 3080-3087.
- Kaffarnik, M.F., N. Ahmadi, J.F. Lock, T. Wuensch, J. Pratschke, M. Stockmann, and M. Malinowski, Correlation between plasma endothelin-1 levels and severity of septic liver failure quantified by maximal liver function capacity (LiMAx test). A prospective study. PLoS One, 2017. 12(5): p. e0178237.
- Lock, J.F., T. Westphal, T. Rubin, M. Malinowski, A. Schulz, M. Jara, J. Bednarsch, and M. Stockmann, LiMAx Test Improves Diagnosis of Chemotherapy-Associated Liver Injury Before Resection of Colorectal Liver Metastases. Ann Surg Oncol, 2017. 24(9): p. 2447-2455.
- Rubin, T.M., K. Heyne, A. Luchterhand, B. Jan, W.R.V. F, G. Polychronidis, M. Malinowski, A. Nikolic, H.M. Tautenhahn, M. Jara, T. Wunsch, M. Stockmann, and J. Friso Lock, Kinetic validation of the LiMAx test during 10 000 intravenous (13)C-methacetin breath tests. J Breath Res, 2017. 12(1): p. 016005.
- Stockmann, M., J. Bednarsch, M. Malinowski, E. Bluthner, J. Pratschke, D. Seehofer, and M. Jara, Functional considerations in ALPPS - consequences for clinical management. HPB (Oxford), 2017. 19(11): p. 1016-1025.
- Reichert, M.C., J. Kupcinskas, M. Krawczyk, C. Jungst, M. Casper, F. Grunhage, B. Appenrodt, V. Zimmer, S.N. Weber, A. Tamelis, J.I. Lukosiene, N. Pauziene, G. Kiudelis, L. Jonaitis, C. Schramm, T. Goeser, A. Schulz, M. Malinowski, M. Glanemann, L. Kupcinskas, and F. Lammert, A Variant of COL3A1 (rs3134646) Is Associated With Risk of Developing Diverticulosis in White Men. Dis Colon Rectum, 2018. 61(5): p. 604-611.
- Bluthner, E., J. Bednarsch, M. Malinowski, P. Binder, J. Pratschke, M. Stockmann, and M. Kaffarnik, Dynamic liver function is an independent predictor of recurrence-free survival after curative liver resection for HCC - A retrospective cohort study. Int J Surg, 2019. 71: p. 56-65.
- Bluthner, E., M. Jara, R. Shrestha, W. Faber, J. Pratschke, M. Stockmann, and M. Malinowski, The predictive value of future liver remnant function after liver resection for HCC in noncirrhotic and cirrhotic patients. HPB (Oxford), 2019. 21(7): p. 912-922.
- Jara, M., T. Dziodzio, M. Malinowski, K. Luttgert, R. Nikolov, P.V. Ritschl, R. Ollinger, J. Pratschke, and M. Stockmann, Prospective Assessment of Liver Function by an Enzymatic Liver Function Test to Estimate Short-Term Survival in Patients with Liver Cirrhosis. Dig Dis Sci, 2019. 64(2): p. 576-584.
- Rohwer, N., S. Jumpertz, M. Erdem, A. Egners, K.T. Warzecha, A. Fragoulis, A.A. Kuhl, R. Kramann, S. Neuss, I. Rudolph, T. Endermann, C. Zasada, I. Apostolova, M. Gerling, S. Kempa, R. Hughes, C.E. Lewis, W. Brenner, M. Malinowski, M. Stockmann, L. Schomburg, W. Faller, O.J. Sansom, F. Tacke, M. Morkel, and T. Cramer, Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis. Oncogene, 2019. 38(28): p. 5670-5685.
- Theilig, D., I. Steffen, M. Malinowski, M. Stockmann, D. Seehofer, J. Pratschke, B. Hamm, T. Denecke, and D. Geisel, Predicting liver failure after extended right hepatectomy following right portal vein embolization with gadoxetic acid-enhanced MRI. Eur Radiol, 2019. 29(11): p. 5861-5872.
- Reichert, M.C., A. Schulz, A. Massmann, A. Buecker, M. Glanemann, F. Lammert, and M. Malinowski, Predictive Power of Liver Maximum Function Capacity Test in Transjugular Intrahepatic Portosystemic Shunt Patients: A Pilot Study. Dig Dis, 2020. 38(3): p. 251-258.
- Theilig, D., A. Tsereteli, A. Elkilany, P. Raabe, L. Ludemann, M. Malinowski, M. Stockmann, J. Pratschke, B. Hamm, T. Denecke, and D. Geisel, Gd-EOB-DTPA-enhanced MRI T1 relaxometry as an imaging-based liver function test compared with (13)C-methacetin breath test. Acta Radiol, 2020. 61(3): p. 291-301.
- Reichert, M.C., J. Kupcinskas, A. Schulz, C. Schramm, S.N. Weber, M. Krawczyk, C. Jungst, M. Casper, F. Grunhage, B. Appenrodt, V. Zimmer, A. Tamelis, J.I. Lukosiene, N. Pauziene, G. Kiudelis, L. Jonaitis, T. Goeser, M. Malinowski, M. Glanemann, L. Kupcinskas, and F. Lammert, Common variation in FAM155A is associated with diverticulitis but not diverticulosis. Sci Rep, 2020. 10(1): p. 1658.
- Bluthner, E., M. Jara, R. Shrestha, W. Faber, J. Pratschke, M. Stockmann, and M. Malinowski, Future liver remnant function as a predictor of postoperative morbidity following liver resection for hepatocellular carcinoma - A risk factor analysis. Surg Oncol, 2020. 33: p. 257-265.
- Reichert, M.C., A. Massmann, A. Schulz, A. Buecker, M. Glanemann, F. Lammert, and M. Malinowski, Volume-Function Analysis (LiMAx Test) in Patients with HCC and Cirrhosis Undergoing TACE-A Feasibility Study. Dig Dis Sci, 2020.
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